Mixed use

The effects triggered by combining two or more substances are difficult to predict. As a rule, they do not simply add up to the sum of the individual effects: mixing substances carries additional health risks, some of which can be severe. Depending on the substances involved, the respective effects may be amplified (sometimes many times over), or they may affect the body and mind in different ways. Both scenarios are extremely stressful for users. The risk of adverse incidents increases with mixed use. Anyone mixing substances should avoid particularly risky combinations (see Combi Compass, further down on this page, or online at SaferMix).

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Safer Use

In any case, it is important to first know the effects of the substances individually and at least wait for the full effect of one substance before consuming the next. Remember that different substances take different amounts of time to reach their maximum effect.

Because of the high strain on the liver and kidneys, it is important to drink plenty of (non-alcoholic) fluids. Alcohol generally alters the effect of other psychoactive substances.

If you use uppers (e.g. amphetamine) to delay coming down, you increase the hangover. Downers to come down also prolong the hangover and usually have a high potential for dependence.

The principle of drug, set and setting should be observed.

It is advisable to tell friends or acquaintances in advance which substances have been mixed during consumption.

Anyone taking medication should seek medical advice in advance about possible risky interactions with psychoactive substances (impairment of the effectiveness of the medication, serious complications, etc.).

More information on interactions between HIV medication and various psychoactive substances

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Celebrate properly

• Avoid mixing several substances
• Psychoactive substances take different amounts of time to have an effect. Therefore, wait at least two hours and do not add alcohol right away.
• Always test a small amount of the substance first on
• Use drug checking services if possible
• Get fresh air regularly at the party
• Drink 3-5 dl of water or soft drinks every hour. At very high temperatures even more!
• Plan enough time to rest. Rest and relaxation are also very important after a high. Healthy food and vitamins strengthen your defences and regenerate your body.
• Sex only with condom!
• If you have consumed something: Hands off the wheel!
• Do not consume alone and keep an eye on your friends. Don't leave anyone alone in case of problems and call the ambulance if necessary (Tel. 144).
• Legal does not mean harmless. Legal substances (smart drugs/natural drugs etc.) are not harmless and pose just as many dangers as illegal substances.
• Consumption, acquisition, possession and trafficking of most drugs are punishable by law

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Combi Compass

The Combi Compass illustrates the risks associated with combining different substances and helps users better assess potential interactions. The assessment should be viewed as a guide and reflects the current state of medically validated knowledge. However, factors such as dosage, purity, method of use, and physical and mental state can significantly influence the risk. You can download the Combi Compass PDFs here.

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