Amitriptyline is approved for the treatment of depression and is used for all forms of depressive disorders. Amitriptyline is also approved for the long-term treatment of pain.
Forms of appearance:
As a medicine
Amitriptyline acts in the central nervous system as an inhibitor of monoamine reuptake. In this way, the concentration of the neurotransmitters serotonin and noradrenalin increases. The depressive symptoms are reduced by the modified sensitivity of the receptors for monoamines. The increase in sensitivity is the reason why the mood-lifting effect usually only occurs after a certain period of intake (approx. after 2-3 weeks). In addition, amitriptyline has effects on other transmission processes in the brain, for example it has a slight antihistaminic effect. This results in a rather dampening overall effect.
The most common side effects include central nervous disorders such as headache, dizziness, tremor, drowsiness, cardiovascular disorders, dry mouth, constipation, nausea and sweating. In addition, confusion, concentration difficulties, libido reduction, hypomania, mania, anxiety, paradoxical insomnia and nightmares are possible.
Due to the risk of a possibly life-threatening serotonin syndrome, amitriptyline must not be used simultaneously with MAO inhibitors!
Refrain from mixed use, as unknown and unpleasant interactions can occur, and have your amphetamine chemically analysed whenever possible.