Amitriptyline

Amitriptyline acts in the central nervous system as an inhibitor of monoamine reuptake. In this way, the concentration of the neurotransmitters serotonin and noradrenalin increases. The depressive symptoms are reduced by the modified sensitivity of the receptors for monoamines. The increase in sensitivity is the reason why the mood-lifting effect usually only occurs after a certain period of intake (approx. after 2-3 weeks). In addition, amitriptyline has effects on other transmission processes in the brain, for example it has a slight antihistaminic effect. This results in a rather dampening overall effect.

Effect

Risks

Safer Use