Quick info
DMT and the closely related 5-MeO-DMT are natural psychoactive tryptamines that occur in plants, animals and humans. They belong to the group of psychedelics.
The effect depends very much on the set and the setting. Blood pressure and pulse increase, pupils dilate. Detachment of the body from the mind and ego dissolution are common, near-death experiences also occur relatively often, especially when high doses are consumed. The perception of time changes greatly during intoxication. A few minutes can be perceived as very long and intense. In addition, different feelings such as fear, euphoria, etc. can be experienced within a short period of time. Consumers report immersion in very "bizarre" worlds in which connections between being, environment and matter arise. With DMT, this phenomenon is also visually pronounced, i.e., images are linked with oneself, matter and being in one's own society. Physical perception can also be influenced, in that one feels weightless or thinks one is falling. With 5-MeO-DMT, the potential effect is greater, but less optical than with DMT.
When swallowed, DMT is only effective in combination with MAO inhibitors. MAO inhibitors (e.g. harmine) are substances and drugs that prevent the enzyme MAO from breaking down the body's own messenger substances such as adrenaline, dopamine, serotonin etc. as well as foreign alkaloids such as caffeine, cocaine, morphine. The psychoactive potion ayahuasca and changa are such a combination. After the consumption of MAO inhibitors, the consumption of certain everyday foods such as cheese is life-threatening.
Dosage
DMT smoked: 15 - 60 mg (only possible in a glass pipe).
DMT snorted: 20 - 50 mg
DMT swallowed: 30 - 150 mg
Changa: Depending on the actual DMT content
Ayahuasca: Depending on the actual DMT content
5-MeO-DMT smoked 2 - 15 mg
5-MeO-DMT snorted: 2 - 20 mg
5-MeO-DMT injected 2 - 3 mg
5-MeO-DMT must be dosed very carefully, as even a few milligrams more can cause a very intense and unpleasant effect that can involve psychological and mental problems lasting several weeks.
Appearances
DMT: resin, powder or tarry mass.
5-MeO-DMT: crystalline mixture.
Ayahuasca is a shamanic herbal potion made from DMT-containing chacruna leaves (Psychotria viridis) and the harmaline-containing ayahuasca liana Banisteriopsis caapi. Harmaline is an MAO inhibitor. MAO inhibitors are substances and drugs that prevent the enzyme MAO from breaking down the body's own messenger substances such as adrenalin, dopamine, serotonin, etc. as well as foreign alkaloids such as caffeine, cocaine, etc.. MAO normally also degrades the active substance DMT even before it can enter the central nervous system via the blood-brain barrier.
Changa is a mixture for smoking of DMT-containing plants (but usually mostly crystalline DMT) and herbs that act as MAO inhibitors.
Onset of action
DMT smoked: after a few seconds
DMT swallowed: after 30 - 60 minutes
5-MeO-DMT smoked: after a few seconds
5-MeO-DMT snorted: after a few minutes.
Duration of action
DMT smoked: 5 - 20 minutes
Ayahuasca: 1 - 6 hours, but may linger for 1 - 8 hours (!). Higher doses of ayahuasca lead to a prolongation of the effect.
5-MeO DMT smoked: 5 - 20 minutes
5-MeO-DMT snorted: 30 - 45 minutes The high usually lasts for 1 - 2 hours.
The risk associated with the use of DMT/5MeO-DMT is mainly psychological and depends on the personality structure of the user. The perceptual changes during a trip can be so intense that especially inexperienced users feel overwhelmed by the flood of impressions. The perception of sudden emotional outbursts can also be perceived as rather disturbing and overwhelming. At high doses, especially with 5-MeO-DMT, such psychological side effects can be felt for days to weeks. If the rules of the set and setting are not followed, there can be false reactions, loss of orientation, panic, paranoia and horror trips. Physical side effects include nausea, vomiting, increase in heart rate, slightly accelerated breathing, increased blood pressure, pupil dilation, increased salivation, tremors, restlessness, headaches and movement disorders.
Long-term risks
Permanent disturbances in self- and reality recognition are possible. The worldview may be permanently challenged, which can make it difficult to cope with everyday life. Latent (hidden) psychoses may be triggered.
Take DMT/5-MeO-DMT while sitting or lying down, as physical perception and ability to move are impaired during intoxication.
The consumption of MAO-inhibiting foods such as matured cheese, smoked fish or meat, sauerkraut, tofu, chocolate etc. should be avoided before and after consumption.
People with high blood pressure should not consume DMT/5-MeO-DMT.
Use DMT/5-MeO-DMT only well-prepared in a stress-free environment (no party drugs!), in which you feel comfortable. Preferably with experienced friends you trust (favorable setting).
Take DMT/5-MeO-DMT only when you feel in good mental and physical condition (favorable set).
You should not be afraid, but have enough respect for the effect.
In delicate moments during the trip: let yourself go, try not to fight the effect. A trip sitter can help you.
In case of panic attacks or horror trips: see General Information under Emergency.
Dextrose can help against circulatory problems.
Avoid roads and other "dangerous" places, your orientation may be impaired.
Psychedelic trips should remain exceptional experiences and should definitely not be experienced more than once a month.
After the trip, allow yourself plenty of rest and recovery, at least the day after, to be able to process the experience.
Persons with mental problems or illnesses, persons taking neuroleptics, and persons with circulatory and cardiac problems should refrain from consuming DMT/5-MeO-DMT.
Refrain from mixed consumption! Taking DMT/5-MeO-DMT with alcohol or various medicines (especially MAO inhibitors) can lead to extremely strong and/or unpleasant side effects, for example extremely high blood pressure.
Refrain from mixed use with lithium. There is an increased risk of psychosis and stroke.
Do not consume tramadol if you use psychedelic substances. Tramadol lowers the threshold for strokes, while psychedelic substances can trigger them in susceptible individuals.
Cannabis can have unexpected strong effects in combination with psychedelic substances, leading to anxiety, panic attacks and paranoia. Mixed use is discouraged or recommended, dosing cannabis lower than usual and taking long breaks in between.
LSD analogues are substances that are chemically very similar to LSD and can have comparable effects. Some of them have been known for a long time (e.g. ALD52, ETH-LAD, AL-LAD, PRO-LAD etc.) and have been studied pharmacologically as well as psychopharmacologically, at least in part. Others are newer "creations" (e.g. the derivatives 1P-LSD,1B-LSD, 1cP-LSD, 1V-LSDetc.), for which only few or no data are available. Certain LSD analogues can (still) be legally produced, traded and consumed in some countries, which is the main reason for their distribution.
Most LSD analogues are naturally different from LSD in their effect and/or potency (e.g. ETH-LAD, AL-LAD, LSZ etc.). In contrast, the so-called 1-acylated LSD compounds (e.g. 1P-LSD, 1V-LSD, 1B-LSD, ALD-52, etc.) are presumed, on the basis of pharmacological studies, to convert into LSD in the body (they function as so-called prodrugs) and thus have a comparable psychoactive effect to LSD.
In the case of prodrugs of LSD and LSD analogues, it has not been conclusively clarified whether, in addition to their psychoactive effect, they can produce other pharmacological effects. How potent these prodrugs are compared to the resulting substance (e.g., 1P-LSD to LSD), and to what extent a delay in onset of action occurs in each case, may be substance-dependent and cannot be generalized. Therefore, it is important to approach the dose/effect carefully to avoid overdoses.
If you or someone else needs urgent help after taking drugs or alcohol, call an ambulance on 144. Tell the emergency responders everything you know.
It could save lives.