Quick info

DMT (N,N-dimethyltryptamine) is a naturally occurring psychedelic found in plants, animals and humans, but is usually sold in extracted form as a crystalline powder.

Changa is a mixture of plants containing DMT (usually crystalline DMT) and herbs for smoking

Ayahuasca is a shamanic herbal potion made from DMT-containing chacruna leaves (Psychotria viridis) and the harmaline-containing ayahuasca liana Banisteriopsis caapi. 

5-MeO-DMT is structurally related to DMT and is usually present in crystalline form. The effect is comparable to that of DMT, but 5-MeO-DMT is more potent than DMT and is therefore dosed much lower.

Effect

Dosage

Risks

Safer Use

Mixed use

Sex

Extender

LSD analogues

Synthesis impurities

Contents

Effect

With smoked and snorted DMT, the onset of effect is usually perceived as overwhelming in terms of speed and intensity. With all forms of consumption, euphoric feelings can arise as well as an altered, greatly slowed sense of time. Immersion in very bizarre worlds, separation of body and mind, ego dissolution, and a sense of oneness with matter are often experienced. Physical effects include increased blood pressure and pulse, and dilation of the pupils.

Duration

Onset of action
DMT
Smoked: after a few seconds
Swallowed: after 30 - 60 minutes

5-MeO-DMT
smoked: after a few seconds
snorted: after a few minutes

Duration of effect
DMT
smoked: 5 - 20 minutes

Ayahuasca:
1 - 6 hours, but can linger for 1 - 8 hours (!). Higher doses of ayahuasca lead to a prolongation of the effect.

5-MeO-DMT
smoked: 5 - 20 minutes
snorted: 30 - 45 minutes The high usually lingers for 1 - 2 hours.

Dosage

Dosage
DMT
smoked: 15 - 60 mg (only possible in a glass pipe)
snorted: 20 - 50 mg
swallowed: 30 - 150 mg

Changa:
Depending on the actual DMT content.

Ayahuasca:
Dependent on actual DMT content.

5-MeO-DMT
smoked 2 - 15 mg
snorted: 2 - 20 mg
injected 2 - 3 mg

5-MeO-DMT must be dosed very carefully, as even a few milligrams more can cause a very intense and unpleasant effect that can involve psychological and mental problems lasting several weeks.

Appearances

DMT:
Resin, powder or tarry mass

5-MeO-DMT:
crystalline mixture

Ayahuasca is a shamanic herbal potion made from DMT-containing chacruna leaves (Psychotria viridis) and the harmaline-containing ayahuasca liana Banisteriopsis caapi. Harmaline is an MAO inhibitor. MAO inhibitors are substances and drugs that prevent the enzyme MAO from breaking down both endogenous messengers such as adrenaline, dopamine, serotonin, etc., and foreign alkaloids such as caffeine, cocaine, etc. MAO normally also degrades the active substance DMT even before it can enter the central nervous system via the blood-brain barrier.

Changa is a mixture for smoking of DMT-containing plants (but usually mostly crystalline DMT) and herbs that act as MAO inhibitors.

Risks

  • The effects triggered by a combination of two or more substances are difficult to assess. As a rule, they do not correspond to the sum of the individual effects: Mixing involves additional, sometimes high health risks.
  • Avoid mixed consumption! Taking DMT/Changa/Ayahuasca/5-MeO-DMT with alcohol or various medications (especially MAO inhibitors) can lead to extremely strong and/or unpleasant side effects, such as extremely high blood pressure.
  • Mixed use with stimulants (e.g. cocaine, amphetamine, methamphetamine) can increase anxiety levels and the risk of thought loops that can lead to negative experiences.
  • Refrain from mixed use with lithium. There is an increased risk of psychosis and stroke.
  • Do not consume tramadol if you use psychedelic substances. Tramadol lowers the threshold for strokes, while psychedelic substances can trigger them in susceptible individuals.
  • Cannabis can have unexpected strong effects in combination with psychedelic substances, leading to anxiety, panic attacks and paranoia. Mixed use is discouraged or recommended, dosing cannabis lower than usual and taking long breaks in between.

Safer Use

  • Take DMT/5-MeO-DMT while sitting or lying down, as physical perception and ability to move are impaired during intoxication.
  • The consumption of MAO-inhibiting foods such as matured cheese, smoked fish or meat, sauerkraut, tofu, chocolate etc. should be avoided before and after consumption.
  • People with high blood pressure should not consume DMT/5-MeO-DMT.
  • Use DMT/5-MeO-DMT only well-prepared in a stress-free environment (no party drugs!), in which you feel comfortable. Preferably with experienced friends you trust (favorable setting).
  • Take DMT/5-MeO-DMT only when you feel in good mental and physical condition (favorable set).
  • You should not be afraid, but have enough respect for the effect.
  • In delicate moments during the trip: let yourself go, try not to fight the effect. A trip sitter can help you.
  • In case of panic attacks or horror trips: see General Information under Emergency.
  • Dextrose can help against circulatory problems.
  • Avoid roads and other "dangerous" places, your orientation may be impaired.
  • Psychedelic trips should remain exceptional experiences and should definitely not be experienced more than once a month.
  • After the trip, allow yourself plenty of rest and recovery, at least the day after, to be able to process the experience.
  • People with mental health problems or illnesses, people taking neuroleptics and people with circulatory and heart problems should refrain from consuming DMT/Changa/Ayahuasca/5-MeO-DMT

Mixed use

  • The effects triggered by a combination of two or more substances are difficult to assess. As a rule, they do not correspond to the sum of the individual effects: Mixing involves additional, sometimes high health risks.
  • Avoid mixed consumption! Taking DMT/Changa/Ayahuasca/5-MeO-DMT with alcohol or various medications (especially MAO inhibitors) can lead to extremely strong and/or unpleasant side effects, such as extremely high blood pressure.
  • Mixed use with stimulants (e.g. cocaine, amphetamine, methamphetamine) can increase anxiety levels and the risk of thought loops that can lead to negative experiences.
  • Refrain from mixed use with lithium. There is an increased risk of psychosis and stroke.
  • Do not consume tramadol if you use psychedelic substances. Tramadol lowers the threshold for strokes, while psychedelic substances can trigger them in susceptible individuals.
  • Cannabis can have unexpected strong effects in combination with psychedelic substances, leading to anxiety, panic attacks and paranoia. Mixed use is discouraged or recommended, dosing cannabis lower than usual and taking long breaks in between.
Cocaine

Lower risk

Learn about the substances, their effects, how quickly they take effect, and the proper dosage. Get to know each substance on its own first, and see how they affect you and whether they suit you before mixing them. Allow enough time between doses, mix as few substances as possible, and start with low doses.

More about poly-drug use

Risk

This combination already poses a significant risk. The effects can reinforce each other or change in unpredictable ways. Therefore, use these substances with caution, test new or unfamiliar substances individually first, and keep the doses as low as possible. Allow sufficient time between doses and avoid taking additional doses on a whim. Be aware of the varying durations of action for each substance.

More about poly-drug use

Increased risk

We strongly advise against this combination. If possible, stick to a single substance. The health risks are significantly increased—including the risk of overdose, respiratory and circulatory problems, and mental health crises.

More about poly-drug use

Increased risk

We strongly advise against this combination. If possible, stick to a single substance. The health risks are significantly increased—including the risk of overdose, respiratory and circulatory problems, and mental health crises.

More about poly-drug use

Risk

This combination already poses a significant risk. The effects can reinforce each other or change in unpredictable ways. Therefore, use these substances with caution, test new or unfamiliar substances individually first, and keep the doses as low as possible. Allow sufficient time between doses and avoid taking additional doses on a whim. Be aware of the varying durations of action for each substance.

More about poly-drug use

Risk

This combination already poses a significant risk. The effects can reinforce each other or change in unpredictable ways. Therefore, use these substances with caution, test new or unfamiliar substances individually first, and keep the doses as low as possible. Allow sufficient time between doses and avoid taking additional doses on a whim. Be aware of the varying durations of action for each substance.

More about poly-drug use

Risk

This combination already poses a significant risk. The effects can reinforce each other or change in unpredictable ways. Therefore, use these substances with caution, test new or unfamiliar substances individually first, and keep the doses as low as possible. Allow sufficient time between doses and avoid taking additional doses on a whim. Be aware of the varying durations of action for each substance.

More about poly-drug use

Risk

This combination already poses a significant risk. The effects can reinforce each other or change in unpredictable ways. Therefore, use these substances with caution, test new or unfamiliar substances individually first, and keep the doses as low as possible. Allow sufficient time between doses and avoid taking additional doses on a whim. Be aware of the varying durations of action for each substance.

More about poly-drug use

Risk

This combination already poses a significant risk. The effects can reinforce each other or change in unpredictable ways. Therefore, use these substances with caution, test new or unfamiliar substances individually first, and keep the doses as low as possible. Allow sufficient time between doses and avoid taking additional doses on a whim. Be aware of the varying durations of action for each substance.

More about poly-drug use

Risk

This combination already poses a significant risk. The effects can reinforce each other or change in unpredictable ways. Therefore, use these substances with caution, test new or unfamiliar substances individually first, and keep the doses as low as possible. Allow sufficient time between doses and avoid taking additional doses on a whim. Be aware of the varying durations of action for each substance.

More about poly-drug use

Lower risk

Learn about the substances, their effects, how quickly they take effect, and the proper dosage. Get to know each substance on its own first, and see how they affect you and whether they suit you before mixing them. Allow enough time between doses, mix as few substances as possible, and start with low doses.

More about poly-drug use

Risk

This combination already poses a significant risk. The effects can reinforce each other or change in unpredictable ways. Therefore, use these substances with caution, test new or unfamiliar substances individually first, and keep the doses as low as possible. Allow sufficient time between doses and avoid taking additional doses on a whim. Be aware of the varying durations of action for each substance.

More about poly-drug use

Lower risk

Learn about the substances, their effects, how quickly they take effect, and the proper dosage. Get to know each substance on its own first, and see how they affect you and whether they suit you before mixing them. Allow enough time between doses, mix as few substances as possible, and start with low doses.

More about poly-drug use

Lower risk

Learn about the substances, their effects, how quickly they take effect, and the proper dosage. Get to know each substance on its own first, and see how they affect you and whether they suit you before mixing them. Allow enough time between doses, mix as few substances as possible, and start with low doses.

More about poly-drug use

Lower risk

Learn about the substances, their effects, how quickly they take effect, and the proper dosage. Get to know each substance on its own first, and see how they affect you and whether they suit you before mixing them. Allow enough time between doses, mix as few substances as possible, and start with low doses.

More about poly-drug use

Risk

This combination already poses a significant risk. The effects can reinforce each other or change in unpredictable ways. Therefore, use these substances with caution, test new or unfamiliar substances individually first, and keep the doses as low as possible. Allow sufficient time between doses and avoid taking additional doses on a whim. Be aware of the varying durations of action for each substance.

More about poly-drug use

Extender

We are not aware of any extenders for DMT/Changa/Ayahuasca/5-MeO-DMT.

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Emergency

If you or someone else needs urgent help after taking drugs or alcohol, call an ambulance on 144. Tell the emergency responders everything you know.
It could save lives.

Things to know

Current warnings

Advisory service