Quick info
DMT (N,N-dimethyltryptamine) is a natural - in plants, animals and humans - occurring psychedelic, but is mostly offered in extracted form as crystalline powder. In certain types of use (ayahuasca and changa), DMT is combined with an MAO inhibitor.
With smoked and snorted DMT, the onset of effect is usually perceived as overwhelming in terms of speed and intensity. With all forms of consumption, euphoric feelings can arise as well as an altered, greatly slowed sense of time. Immersion in very bizarre worlds, separation of body and mind, ego dissolution, and a sense of oneness with matter are often experienced. Physical effects include increased blood pressure and pulse, and dilation of the pupils.
Onset of action
DMT
Smoked: after a few seconds
Swallowed: after 30 - 60 minutes
5-MeO-DMT
smoked: after a few seconds
snorted: after a few minutes
Duration of effect
DMT
smoked: 5 - 20 minutes
Ayahuasca:
1 - 6 hours, but can linger for 1 - 8 hours (!). Higher doses of ayahuasca lead to a prolongation of the effect.
5-MeO-DMT
smoked: 5 - 20 minutes
snorted: 30 - 45 minutes The high usually lingers for 1 - 2 hours.
Dosage
DMT
smoked: 15 - 60 mg (only possible in a glass pipe)
snorted: 20 - 50 mg
swallowed: 30 - 150 mg
Changa:
Depending on the actual DMT content.
Ayahuasca:
Dependent on actual DMT content.
5-MeO-DMT
smoked 2 - 15 mg
snorted: 2 - 20 mg
injected 2 - 3 mg
5-MeO-DMT must be dosed very carefully, as even a few milligrams more can cause a very intense and unpleasant effect that can involve psychological and mental problems lasting several weeks.
Appearances
DMT:
Resin, powder or tarry mass
5-MeO-DMT:
crystalline mixture
Ayahuasca is a shamanic herbal potion made from DMT-containing chacruna leaves (Psychotria viridis) and the harmaline-containing ayahuasca liana Banisteriopsis caapi. Harmaline is an MAO inhibitor. MAO inhibitors are substances and drugs that prevent the enzyme MAO from breaking down both endogenous messengers such as adrenaline, dopamine, serotonin, etc., and foreign alkaloids such as caffeine, cocaine, etc. MAO normally also degrades the active substance DMT even before it can enter the central nervous system via the blood-brain barrier.
Changa is a mixture for smoking of DMT-containing plants (but usually mostly crystalline DMT) and herbs that act as MAO inhibitors.
The risk associated with the use of DMT and 5MeO-DMT lies primarily in the psychological area and depends on the personality structure of the user. The perceptual changes during a trip can be so intense that inexperienced users in particular feel overwhelmed by the flood of impressions. Perceiving sudden bursts of emotion can also be perceived as rather disturbing and overwhelming. At high doses, especially 5-MeO DMT, such psychological side effects can be felt for days to weeks. If the rules of the set and setting are not followed, there may be false reactions, loss of orientation, panic, paranoia, and horror trips. Physical side effects include nausea, vomiting, increase in heart rate, slightly accelerated breathing, increased blood pressure, pupil dilation, increased salivation, tremors, restlessness, headaches, and movement disorders.
Long-term risks
Permanent disturbances in self- and reality recognition are possible. The worldview may be permanently challenged, which can make it difficult to cope with everyday life. Latent (hidden) psychoses may be triggered.
LSD analogues are substances that are chemically very similar to LSD and can have comparable effects. Some of them have been known for a long time (e.g. ALD52, ETH-LAD, AL-LAD, PRO-LAD etc.) and have been studied pharmacologically as well as psychopharmacologically, at least in part. Others are newer "creations" (e.g. the derivatives 1P-LSD,1B-LSD, 1cP-LSD, 1V-LSDetc.), for which only few or no data are available. Certain LSD analogues can (still) be legally produced, traded and consumed in some countries, which is the main reason for their distribution.
Most LSD analogues are naturally different from LSD in their effect and/or potency (e.g. ETH-LAD, AL-LAD, LSZ etc.). In contrast, the so-called 1-acylated LSD compounds (e.g. 1P-LSD, 1V-LSD, 1B-LSD, ALD-52, etc.) are presumed, on the basis of pharmacological studies, to convert into LSD in the body (they function as so-called prodrugs) and thus have a comparable psychoactive effect to LSD.
In the case of prodrugs of LSD and LSD analogues, it has not been conclusively clarified whether, in addition to their psychoactive effect, they can produce other pharmacological effects. How potent these prodrugs are compared to the resulting substance (e.g., 1P-LSD to LSD), and to what extent a delay in onset of action occurs in each case, may be substance-dependent and cannot be generalized. Therefore, it is important to approach the dose/effect carefully to avoid overdoses.
If you or someone else needs urgent help after taking drugs or alcohol, call an ambulance on 144. Tell the emergency responders everything you know.
It could save lives.