Oxygesic®, OxyContin®, Oxycaloxone®, Oxycocomp ratio®, Targin®, etc.
Oxycodone belongs to the group of active substances known as potent opioid analgesics and is used to treat severe to very severe pain. It is semi-synthetic and twice as potent as morphine. The dependence potential is classified as very high.
Oxycodone has analgesic, depressant, antianxiety, cough suppressant and psychotropic properties. More intense dreams may also occur. Due to its relaxing and euphoric properties, it is used as a recreational drug, and is said to be more stimulating and mood-lifting than other opioids.
Onset of effect
Injected: after a few seconds
Snorted: after 2-3 minutes
Swallowed: after 20-40 minutes
Duration of action
approx. 3-6 hours
As tablets, capsules, drops and solution for injection/infusion. Sustained-release or non-retarded. Also available as a combination preparation with the opioid antagonist naloxone: this to reduce constipation and to make it unattractive for abuse.
Light: 2.5 - 10 mg
Medium: 10 - 25 mg
Strong: 25 - 40 mg
Snuffed (as a nasal spray)
Light: 2.5 - 7.5 mg
Medium: 7.5 - 15 mg
Strong: 15 - 25 mg
When consuming for the first time, low doses should be used, as the risk of respiratory arrest is increased.
Very common side effects, as with all opioids, are constipation and constriction of the pupils. Drowsiness, dizziness, headache, itching, muscle twitching, sleep disturbances and mood swings are also to be expected. In women, menstruation may also be absent.
Other opioid-typical side effects such as hallucinations, confusion, vomiting and nausea are less common with oxycodone.
Overdoses with oxycodone are life-threatening, as the substance has a strong respiratory depressant effect even in low doses when abused, which can lead to respiratory arrest and coma. For opioid addicts, the lethal dose can be much higher. An overdose is treated by taking naloxone, an opioid antagonist.
The consumption of oxycodone leads to physical and psychological dependence after a short time, even more quickly than with morphine. Tolerance builds up, which is why higher and higher doses have to be consumed. Strong withdrawal symptoms such as restlessness, irritability, depression, insomnia, sweating, cold shivers, vomiting, diarrhoea and painful cramps may occur.
Opioids are highly effective medications that should only be used for a limited time and, at best, with a doctor's supervision.
Start with a low dose and wait for the effect and tolerance before adding more.
After a period of abstinence, use a much lower dose! The usual dose before the abstinence phase can otherwise quickly have life-threatening consequences.
If you inject opioids, dose even more carefully, as the range between desired effect (rush) and dangerous overdose is even more difficult to assess. Avoid injecting opioids; the risk of overdose is particularly high. Always use new (clean and sterile) injection material! Never exchange syringes, filters, water, disinfection swabs to avoid transmission of hepatitis and HIV.
Do not rely on dosage information from colleagues who regularly use opioids. Due to habituation or dependence, their doses are significantly higher and can be fatal for new users.
Take longer breaks (at least several days) between consumption.
Refrain from citrus fruits (especially grapefruit) before or during consumption. The combination can lead to an increase in the effect of the opioid and/or respiratory depression.
The simultaneous consumption of depressant substances such as alcohol, ketamine, GHB/GBL, nitrous oxide, benzodiazepines and/or other opioids is dangerous as there is an increased risk of vomiting and unconsciousness. The risk of suffocation is high!
The combination with methoxetamine (MXE, Metha-Keta) increases the opioid effect.
Mixing opioids with DXM is generally not recommended - there is an increased risk of central nervous system disorders as well as heart and respiratory problems. In addition, DXM lowers the individual opioid tolerance, which is why the risk of overdose increases considerably.
Mixed use of opioids with stimulants (such as cocaine, amphetamine, methamphetamine) puts extreme strain on the body and the cardiovascular system. The effects can mask each other, so that they are subjectively felt to be weaker. If the effect of the stimulants wears off before the opioids, there is a risk of delayed overdose and even respiratory depression.
LSD analogues are substances that are chemically very similar to LSD and can have comparable effects. Some of them have been known for a long time (e.g. ALD52, ETH-LAD, AL-LAD, PRO-LAD etc.) and have been studied pharmacologically as well as psychopharmacologically, at least in part. Others are newer "creations" (e.g. the derivatives 1P-LSD,1B-LSD, 1cP-LSD, 1V-LSDetc.), for which only few or no data are available. Certain LSD analogues can (still) be legally produced, traded and consumed in some countries, which is the main reason for their distribution.
Most LSD analogues are naturally different from LSD in their effect and/or potency (e.g. ETH-LAD, AL-LAD, LSZ etc.). In contrast, the so-called 1-acylated LSD compounds (e.g. 1P-LSD, 1V-LSD, 1B-LSD, ALD-52, etc.) are presumed, on the basis of pharmacological studies, to convert into LSD in the body (they function as so-called prodrugs) and thus have a comparable psychoactive effect to LSD.
In the case of prodrugs of LSD and LSD analogues, it has not been conclusively clarified whether, in addition to their psychoactive effect, they can produce other pharmacological effects. How potent these prodrugs are compared to the resulting substance (e.g., 1P-LSD to LSD), and to what extent a delay in onset of action occurs in each case, may be substance-dependent and cannot be generalized. Therefore, it is important to approach the dose/effect carefully to avoid overdoses.
If you or someone else needs urgent help after taking drugs or alcohol, call an ambulance on 144. Tell the emergency responders everything you know.
It could save lives.