Opioids are highly effective medications that should only be used for a limited time and, at best, with a doctor's supervision.
Start with a low dose and wait for the effect and tolerance before adding more. Do not exceed the maximum daily dose.
If you inject opioids, dose even more carefully, as the range between desired effect (rush) and dangerous overdose is even more difficult to assess. Avoid injecting fentanyl; the risk of overdose is particularly high. Always use new (clean and sterile) injection material! Never exchange syringes, filters, water, disinfection swabs to avoid transmission of hepatitis and HIV.
Do not rely on dosage information from colleagues who regularly use opioids. Due to habituation or dependence, their doses are significantly higher and can be fatal for new users.
Take longer breaks (at least several days) between consumption.
After a period of abstinence, use a much lower dose! The usual dose before the abstinence phase can otherwise quickly have life-threatening consequences.
The simultaneous consumption of depressant substances such as alcohol, ketamine, GHB/GBL, nitrous oxide, benzodiazepines and/or other opioids is dangerous as there is an increased risk of vomiting and unconsciousness. The risk of suffocation is high!
Refrain from citrus fruits (especially grapefruit) before or during consumption. The combination can lead to an increase in the effect of the opiate and/or respiratory depression.