Morphine / morphine

Due to its strong analgesic, antitussive and psychotropic properties, morphine is used to treat severe pain in emergency and palliative care.

Due to its depressant and sedative effect, the active substance is also misused as a euphoric intoxicant. In the context of opioid agonist therapy, morphine is used as a substitute for opiate/heroin addiction.

Onset of effect

Injected: after seconds
Swallowed: after approx. 20 minutes (for sustained release tablets after 1 - 1.5 hours)

Duration of action

approx. 3 - 6 hours

Swallowed:

Light: 5 - 10 mg
Medium: 15 - 20 mg
Strong: over 25 mg

When consuming for the first time, low doses should be used, as the risk of respiratory arrest is increased.

• Mixing with other downers (alcohol, benzodiazepines, drugs, GHB/GBL, heroin, opioids) can lead to dangerous interactions and an intensification of the effect and there is a risk of respiratory depression up to respiratory paralysis, a drop in blood pressure, a coma and in the worst case can lead to death!

• The combination with methoxetamine (MXE, Metha-Keta) increases the opioid effect.
• Mixed use of opiates with DXM is generally not recommended - there is an increased risk of central nervous system disorders as well as cardiac and respiratory problems. In addition, DXM lowers the individual opiate tolerance, which is why the risk of overdose increases considerably.
• The mixed use of opiates with stimulants (such as cocaine, amphetamine, methamphetamine) puts extreme strain on the body and the cardiovascular system. The effects can mask each other, so that they are subjectively felt to be weaker. If the effect of the stimulants wears off before the opiates, there is a risk of delayed overdose and even respiratory depression.
• Morphine should not be consumed with drugs and substances that increase the serotonin concentration. These include MDMA, 4-FA, methamphetamine, methyltryptamine and migraine medications from the group of triptans, tramadol, tapentadol, St. John's wort and MAO inhibitors. These combinations increase the risk of serotonin syndrome. This can be followed by Fever, rise in blood pressure, overheating, diarrhea, seizures, increased reflexes, confusion, coma.

• Opiates are highly effective drugs that should only be used for a limited time and, at best, with a doctor's supervision.
• Start with a low dose and wait for the effect and tolerance before adding more.
• After a period of abstinence, use a much lower dose! The usual dose before the abstinence phase can otherwise quickly have life-threatening consequences.
• If you inject opiates, dose even more carefully, as the range between desired effect (rush) and dangerous overdose is even more difficult to assess. Avoid injecting opiates; the risk of overdose is particularly high. Always use new (clean and sterile) syringe material! Never exchange syringes, filters, water, disinfection swabs to avoid transmission of hepatitis and HIV.
• Do not rely on dosage information from colleagues who regularly use opiates. Due to habituation or dependence, their doses are significantly higher and can be fatal for new users.
• Take longer breaks (at least several days) between consumption.
• Refrain from citrus fruits (especially grapefruit) before or during consumption. The combination can lead to an increase in the effect of the opiate and/or respiratory depression