Tilidine

Tilidine inhibits pain-mediating neuronal systems in the body and thus has a pain-relieving effect. When consumed in higher doses, it has a euphoric and anxiety-relieving effect. Due to its opioid properties, regular use can quickly lead to dependence. Abrupt discontinuation of tilidine leads to withdrawal symptoms.

Onset of action

Drops: after 5 - 10 minutes
Tablets: after 10 - 20 minutes

Duration of action

3 - 5 hours, depending on the form of consumption. In the case of sustained-release tablets, up to 12 hours (active substance is released delayed over a longer period). Side effects can last between 1 and 12 hours.

Appearance

Available in drop or tablet form (retarded and de-retarded). Pure tilidine requires a prescription and is classified as a narcotic.

In Germany, tilidine is only available as a combination preparation with naloxone (8 mg naloxone to 100 mg tilidine). This is intended to prevent misuse of tilidine: At a very high oral dosage or when the drug is injected, naloxone as an opioid antagonist cancels the effect of tilidine. Naloxone is used in emergency medicine for opioid overdoses from heroin, methadone or fentanyl.

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Swallowed:

Light: at approx. 25 - 50 mg psychoactive effects may already occur

Medium: 50 - 75 mg

Strong: Doses of 100 mg or more are considered too strong by many users and increase the risk of respiratory arrest.

With sustained-release tablets there is a risk of overdose due to delayed release of the active ingredient! The perceived effect is extremely different depending on the person and tolerance. In combination preparations with naloxone, the desired psychoactive effect of tilidine is cancelled out from approx. 300 - 400 mg by the naloxone contained.

When consuming for the first time, low doses should be used, as the risk of respiratory arrest is increased.

Mixing with other downers (alcohol, benzodiazepines, drugs, GHB/GBL, heroin, opioids) can lead to dangerous interactions and an intensification of the effect and there is a risk of respiratory depression up to respiratory paralysis, a drop in blood pressure, a coma and in the worst case can lead to death!

The combination with methoxetamine (MXE, Metha-Keta) increases the opioid effect.

Mixing opioids with DXM is generally not recommended - there is an increased risk of central nervous system disorders as well as heart and respiratory problems. In addition, DXM lowers the individual opioid tolerance, which is why the risk of overdose increases considerably.

Mixed use of opioids with stimulants (such as cocaine, amphetamine, methamphetamine) puts extreme strain on the body and the cardiovascular system. The effects can mask each other, so that they are subjectively felt to be weaker. If the effect of the stimulants wears off before the opioids, there is a risk of delayed overdose and even respiratory depression.

Opioids are highly effective medications that should only be used for a limited time and, at best, with a doctor's supervision.

Start with a low dose and wait for the effect and tolerance before adding more.

After a period of abstinence, use a much lower dose! The usual dose before the abstinence phase can otherwise quickly have life-threatening consequences.

If you inject opioids, dose even more carefully, as the range between desired effect (rush) and dangerous overdose is even more difficult to assess. Avoid injecting opioids; the risk of overdose is particularly high. Always use new (clean and sterile) injection material! Never exchange syringes, filters, water, disinfection swabs to avoid transmission of hepatitis and HIV.

Do not rely on dosage information from colleagues who regularly use opioids. Due to habituation or dependence, their doses are significantly higher and can be fatal for new users.

Take longer breaks (at least several days) between consumption.

Refrain from citrus fruits (especially grapefruit) before or during consumption. The combination can lead to an increase in the effect of the opioid and/or respiratory depression.