Quick info

3-CMC (clophedrone, 3-chloromethcathinone) and 4-CMC (clephedrone, 4-chloromethcathinone) are new psychoactive substances and belong to the synthetic cathinones of the amphetamine group. There is hardly any information available on risks, side effects and long-term consequences. It is assumed that 3-CMC and 4-CMC have a very high neurotoxic effect. The chemical structure is similar to that of 3-MMC and 4-MMC (mephedrone). 3-CMC and 4-CMC are often marketed on the Internet as a substitute for mephedrone.

Effect

Dosage

Risks

Safer Use

Mixed use

Sex

Extender

LSD analogues

Synthesis impurities

Contents

Effect

The effect is described as similar to 3-MMC, but milder. Furthermore, 3-CMC and 4-CMC have a stimulating, uplifting, anxiolytic, disinhibiting, slightly euphoric, concentration- and performance-enhancing and libido-increasing effect. An increased urge to talk and a pronounced empathy have also been reported (although to a lesser extent than with MDMA).

Duration

Onset of action:
Snorted: after 10 - 30 minutes
Swallowed: after 30 - 60 minutes

Duration of action:
Snorted: 1 - 2 hours
Swallowed: 2 - 4 hours  

Dosage

Snorted:
‍light
: 20 - 40 mg
medium: 40 - 80 mg
strong: 80 - 100 mg

Swallowed:
light: 30 - 60 mg
medium: 60 - 100mg
strong: 100 - 180 mg    

Little is known about intravenous, rectal, and inhalation use. These forms of use should be avoided. If you do try any of these forms of use, use as low a dose as possible.

Forms of appearance
White to brownish crystalline powder or crystals

Risks

  • Avoid the consumption of 3-CMC, 4-CMC and other serotonin-releasing substances such as MAOIs, MDMA, 4-FA, methamphetamine, methylone, 5-HTP and SSRIs/SNRIs. This can lead to a life-threatening serotonin syndrome!
  • Mixed use with 25x-NBOMe and 25x-NBOH can lead to excessive stimulation with panic attacks, seizures, mind spinning, increased blood pressure, vasoconstriction, and in severe cases can lead to heart failure.
  • Do not take tramadol if you use stimulants. Tramadol and stimulants can both cause strokes, which cumulates the risk.
  • Other potentially harmful combinations cannot be ruled out, as there is no scientifically sound information on interactions with cathinones.

Safer Use

  • There is little knowledge about Cathinone. Therefore, when you use it, you are exposing yourself to unknown risks. Have the substance analyzed in a drug checking. If this is not possible and you still want to use it, try to reach the desired dose by using small amounts.
  • If you decide to use, be as informed as possible about the specific substance and the appropriate dosage - pay attention to your basic mood and the environment in which you use (set and setting), even with NPS.
  • Do not buy a product with a fancy name without declaring the ingredient. Legal does not mean harmless.
  • Inform your friends about what and how much you have consumed.
  • Drink enough non-alcoholic beverages and get some fresh air in between.
  • Accept when the effect runs out, don't add to it right away.
  • Refrain from mixed consumption, as interactions are dangerous and unexplored.
  • Take regular breaks from consumption.
  • People with high blood pressure, heart problems, hyperthyroidism, liver and kidney disease, or circulatory problems should not take New Psychoactive Substances.

Mixed use

  • Avoid the consumption of 3-CMC, 4-CMC and other serotonin-releasing substances such as MAOIs, MDMA, 4-FA, methamphetamine, methylone, 5-HTP and SSRIs/SNRIs. This can lead to a life-threatening serotonin syndrome!
  • Mixed use with 25x-NBOMe and 25x-NBOH can lead to excessive stimulation with panic attacks, seizures, mind spinning, increased blood pressure, vasoconstriction, and in severe cases can lead to heart failure.
  • Do not take tramadol if you use stimulants. Tramadol and stimulants can both cause strokes, which cumulates the risk.
  • Other potentially harmful combinations cannot be ruled out, as there is no scientifically sound information on interactions with cathinones.
Cocaine
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Extender

Since 2023, cathinones such as 3-CMC and 4-CMC have become more popular again and are increasingly being accepted in drug checking offers in Switzerland. The analysis results show that up to 75% of these samples contained synthesis by-products or (additional) ingredients other than the expected active ingredient. If you decide to use it, it is therefore important to have the substance tested first in a drug checking service and/or to test a small amount first.

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Emergency

If you or someone else needs urgent help after taking drugs or alcohol, call an ambulance on 144. Tell the emergency responders everything you know.
It could save lives.

Things to know

Current warnings

Advisory service