Quick info

Lyrica®, Algecia® and PREGABALIN are available as medicines from the following companies: Mepha®, Sandoz®, Spirig®, Viatris®, Xiromed® and Zentiva®.
Pregabalin is an active substance from the group of antiepileptic drugs. The active ingredient is used to prevent epileptic seizures. The active ingredient is also prescribed for anxiety disorders and neuropathic pain (damaged or diseased cells in the nervous system).
Pregabalin has analgesic, antiepileptic, anxiolytic and sedative, anticonvulsant, motivating, relaxing and euphoric effects.
Due to its calming, relaxing and euphoric properties, pregabalin is abused as an intoxicant. Regular use can quickly lead to dependence. Abrupt discontinuation of pregabalin leads to withdrawal symptoms (see long-term risks/consequences).
"Budweiser" is a common street name for pregabalin, supposedly because some 300mg tablets are colored red and white (like the colors of the beer brand Budweiser®) and pregabalin has a similar effect to alcohol.
Onset of effect
With drops (oral) within 5-10 minutes, intravenous: after a few seconds, with tablets after approx. 60 minutes.
Duration of action
Depending on the form of consumption, approx. 6 hours up to 17 hours, up to 12 hours for delayed-release tablets (active ingredient is released with a delay over a longer period of time). After-effects (afterglow) can occur for up to 4-10 hours.
Forms of consumption
Swallowed, injected (intravenously) or rectally. However, intravenous consumption is not recommended due to the often expected undesirable effects.
Appearances
Capsules, solution or in tablet form (retarded and de-retarded available). Pure pregabalin is only available on prescription.
For capsules/tablets
The dosage information refers to total daily doses, which are achieved by taking smaller individual doses throughout the day.
Low daily dose: 50 - 150 mg. Psychoactive effects may already occur at 50 mg.
Average daily dose: 150 - 350 mg.
High daily dose: Doses of 350 - 600 mg. 600 mg is already considered too strong by many consumers. In addition, 600 mg is the maximum dose per day.
If pregabalin is prescribed, the day is divided into three or two doses. For example, 50 mg in the morning, 50 mg at midday and 50 mg in the evening (daily dose 150 mg).
Risks
Known undesirable side effects are dizziness, drowsiness, fatigue (sleepiness), headache, confusion, irritability, depression, disorientation, insomnia, loss of libido (desire for sex decreases), movement disorders, attention, coordination, balance, memory and speech disorders, tremors, tingling, burning or numbness (paraesthesia), reduced sensitivity to touch stimuli, apathy, blurred vision, double vision, dizziness, vomiting, constipation, flatulence, dry mouth, muscle cramps, joint, limb and back pain, cramps in the neck region, feeling drunk, sensory disturbances, exhaustion.
Overdose
At higher doses, affective disorders (mood and physical drive are not in balance over a longer period of time), drowsiness, states of confusion, depression, urge to move and restlessness may occur. Rare cases of cardiac arrhythmia, seizures and coma have been reported.
The anxiolytic, disinhibiting and euphoric properties can lead to aggression, loss of control and an increased willingness to take risks.
Long-term risks/consequences
Regular, abusive consumption of pregabalin leads to dependence with severe withdrawal symptoms such as restlessness, nervousness, seizures, sleep disorders, irritability, anger, anxiety, panic, chills and depression. As with opioids, for example, withdrawal should not be abrupt and should only take place under medical supervision.
Pregabalin is a highly effective medication that should only be used for a limited period of time and at best under medical supervision.
Start with a low dose and wait for the effect and tolerance before adding more.
Don't get involved in a competition to see who can take the most medication. Under certain circumstances, this can lead to serious adverse health effects. Be sure to say that you don't want to be pressured into taking more pregabalin. If you are using, only take as much as you have already experienced and you know the effects. Otherwise, take a low dose first and get to know the substance. Once you have taken the substance, it is in your body and must be eliminated.
After a period of abstinence, reduce the dose considerably! After long breaks (several months), low doses should be taken again to avoid overdosing. Otherwise this can quickly have harmful consequences for your health.
Avoid mixed consumption with downers such as alcohol, benzodiazepines, anxiolytics, antidepressants, antihistamines, opioids and opiates. The combination leads to an intensification of the effects with possible life-threatening consequences (respiratory depression, cardiac arrest, etc.). If you nevertheless consume several substances together, take only a little of each substance!
Do not rely on dosage information from colleagues who regularly use pregabalin. Due to habituation or dependence, their doses are significantly higher and can be fatal for new users.
Take longer breaks between use (at least several days). Regular use can quickly lead to psychological and physical dependence.
When consuming pregabalin, mixed consumption should be avoided!
Mixed consumption with alcohol and other downers (such as benzodiazepines, especially the active ingredient lorazepam; opiates, especially the active ingredient oxycodone; barbiturates) can lead to dangerous interactions. This can lead to an intensification of the effect, which is stressful for the cardiovascular system and, in the worst case, there is a risk of respiratory arrest, respiratory depression and cardiac arrest, which can lead to coma and death.
Mixed consumption with stimulants (such as cocaine, amphetamine, methamphetamine) puts extreme strain on the body and the cardiovascular system. The effects can mask each other, so that they are subjectively felt to be weaker and are subsequently dosed. If the effect of the stimulants wears off before the pregabalin, there is a risk of a delayed overdose leading to respiratory depression.
Mixed consumption with MDMA can lead to serotonin syndrome.
Ketamine consumption can trigger increased hallucinations, which can quickly become mentally overwhelming for users. It can also lead to immobility or severely restricted mobility.
If you decide to mix substances anyway, take the respective substances in low doses to minimize life-threatening damage.
LSD analogues are substances that are chemically very similar to LSD and can have comparable effects. Some of them have been known for a long time (e.g. ALD52, ETH-LAD, AL-LAD, PRO-LAD etc.) and have been studied pharmacologically as well as psychopharmacologically, at least in part. Others are newer "creations" (e.g. the derivatives 1P-LSD,1B-LSD, 1cP-LSD, 1V-LSDetc.), for which only few or no data are available. Certain LSD analogues can (still) be legally produced, traded and consumed in some countries, which is the main reason for their distribution.
Most LSD analogues are naturally different from LSD in their effect and/or potency (e.g. ETH-LAD, AL-LAD, LSZ etc.). In contrast, the so-called 1-acylated LSD compounds (e.g. 1P-LSD, 1V-LSD, 1B-LSD, ALD-52, etc.) are presumed, on the basis of pharmacological studies, to convert into LSD in the body (they function as so-called prodrugs) and thus have a comparable psychoactive effect to LSD.
In the case of prodrugs of LSD and LSD analogues, it has not been conclusively clarified whether, in addition to their psychoactive effect, they can produce other pharmacological effects. How potent these prodrugs are compared to the resulting substance (e.g., 1P-LSD to LSD), and to what extent a delay in onset of action occurs in each case, may be substance-dependent and cannot be generalized. Therefore, it is important to approach the dose/effect carefully to avoid overdoses.
If you or someone else needs urgent help after taking drugs or alcohol, call an ambulance on 144. Tell the emergency responders everything you know.
It could save lives.