Quick info
The leaves of the tree Mitragyna speciosa, which grows in Southeast Asia, contain psychoactive indole alkaloids and are extremely bitter. The active ingredients bind to opioid receptors, which is why kratom is classified as an opioid, even though it is not an opioid. Kratom is used as a stimulant and intoxicant, for opioid withdrawal, and as a stimulant. In some countries, especially in Southeast Asia, kratom is still legal or legal again.
Kratom has a stimulating, attention-, performance- as well as libido-increasing effect in low doses similar to caffeine. In Southeast Asia, the powder is used in traditional medicine, among other things against diarrhea, inflammation, fever, pain, anxiety and depression. In higher doses, opioid-like effects occur. Then it has analgesic, antianxiety, sedative and euphoric effects. The euphoric effect is described as rather mild. High doses (10-25mg) can lead to a dream-like state.
Dried leaves, chewed or drunk as a tea (rarely smoked):
Light: 2-3g
Medium: 3-5g
Strong: 5-8g
The effect and active ingredient content can vary greatly depending on the dosage and country of origin of the leaves.
Appearances
Fresh or dried leaves, as powder, tea or in capsules.
Onset of effect
After 20-40 minutes.
Duration of action
2-4 hours.
Possible unwanted side effects include nausea, vomiting, indigestion, and dry mouth. Certain varieties can cause extreme fatigue to the point of drowsiness. In addition, psychosis can be induced.
Overdose
High doses, like opioids, can cause respiratory depression.
Long-term risks/consequences
Regular use can lead to physical dependence with withdrawal symptoms such as anxiety, restlessness, sleep disturbances, sweating and craving. In addition, weight loss, fatigue, constipation, bowel obstruction, and hyperpigmentation of the cheeks are other long-term risks.
Take regular breaks from use. As with opioids, tolerance builds up quickly.
Consumption of stomach acid neutralizing drugs (antacids), turmeric with pepper, grapefruit juice, watercress or the dietary supplement agmatine enhances the effect of kratom. There is a risk of overdose.
Depressant drugs such as alcohol, benzodiazepines, antihistamines, ketamine, GHB/GBL, or MAO inhibitors should not be consumed simultaneously with kratom. There is an increased risk of vomiting and unconsciousness up to respiratory depression. The risk of suffocation is high!
Mixed use of kratom with stimulants (such as cocaine, amphetamine, methamphetamine) puts extreme strain on the body and cardiovascular system. The effects can mask each other, so that they are subjectively felt weaker. If the effect of the stimulants wears off before the effect of kratom, there is a risk of delayed overdose up to respiratory depression.
LSD analogues are substances that are chemically very similar to LSD and can have comparable effects. Some of them have been known for a long time (e.g. ALD52, ETH-LAD, AL-LAD, PRO-LAD etc.) and have been studied pharmacologically as well as psychopharmacologically, at least in part. Others are newer "creations" (e.g. the derivatives 1P-LSD,1B-LSD, 1cP-LSD, 1V-LSDetc.), for which only few or no data are available. Certain LSD analogues can (still) be legally produced, traded and consumed in some countries, which is the main reason for their distribution.
Most LSD analogues are naturally different from LSD in their effect and/or potency (e.g. ETH-LAD, AL-LAD, LSZ etc.). In contrast, the so-called 1-acylated LSD compounds (e.g. 1P-LSD, 1V-LSD, 1B-LSD, ALD-52, etc.) are presumed, on the basis of pharmacological studies, to convert into LSD in the body (they function as so-called prodrugs) and thus have a comparable psychoactive effect to LSD.
In the case of prodrugs of LSD and LSD analogues, it has not been conclusively clarified whether, in addition to their psychoactive effect, they can produce other pharmacological effects. How potent these prodrugs are compared to the resulting substance (e.g., 1P-LSD to LSD), and to what extent a delay in onset of action occurs in each case, may be substance-dependent and cannot be generalized. Therefore, it is important to approach the dose/effect carefully to avoid overdoses.
If you or someone else needs urgent help after taking drugs or alcohol, call an ambulance on 144. Tell the emergency responders everything you know.
It could save lives.