Substances / Mescaline

Mescaline is a naturally occurring hallucinogenic substance from the phenethylamine class of substances. Cacti containing mescaline have been used for ritual purposes in Latin America for thousands of years. Mescaline is traditionally used in Latin America by indigenous shamans in rituals.

Mescaline is found in the Central American peyote cactus (Lophophora Williamsii) or the South American cactus genus Trichocereus (T. pachanoi, T. bridgesii, T. peruvianus). Other cactus species, such as the San Pedro cactus native to the Andes region, also contain mescaline.

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Effect

Mescaline intoxication is described as a psychedelic-visionary, ecstatic state accompanied by feelings of happiness, of great clarity but without the metallic sharpness of LSD.

Nausea and vomiting may often occur before the onset of action.

The trip begins with hyperactivity and inner restlessness, then an altered, sharpened perception and an intense visual effect set in.

In the further course it comes to a gentle drifting experience. Visions and a euphoria of religious depth are reported, the connection with something ancient, the feeling of a visionary experience and the change of ego sensation as well as feelings of ego dissolution.

The coming down phase is softer than with other psychedelics.

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Duration

Onset of action
After 45 minutes to 1.5 hours.

Duration of action
8 - 14 hours.

After-effects
6 - 36 hours

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Dosage

Swallowed
light: 50 - 200 mg
medium: 200 - 400 mg
strong: 400 - 800 mg

The mescaline content can vary greatly from plant to plant.

Appearances:
dried, crushed plant material, filled in capsules or directly processed into a decoction.

Risks

The pharmacological effects of mescaline and the bitter taste often lead to nausea in the initial phase of the trip, sometimes to vomiting and diarrhea. In case of vomiting, the user may choke on the vomit (danger of suffocation)!

Other possible side effects are: Increase in pulse and blood pressure, dry mouth, sweating, pupil enlargement, disorientation, confusion, anxiety, increase in body temperature.

Long-term risks
It remains questionable whether the use of mescaline can trigger a latent (hidden) mental disorder. Repeated use over a short period of time may result in tolerance lasting a few days.

Safer Use

Mescaline is not suitable as a party drug and should only be used by experienced users.
Use mescaline only in a well-prepared environment where you feel comfortable and only with experienced friends (good setting) and/or a trip sitter (sober person).
Use mescaline only when you feel good mentally and physically (good set).
You should not be afraid, but have enough respect for the mescaline effects.
Mescaline should be taken on an empty stomach. Fasting before the trip may help to reduce the likelihood of nausea and vomiting.
For nausea, it helps if you take mescaline in small doses at a time.
Don't throw it right away if it doesn't work right away.
Let yourself go during the trip and try not to fight the mescaline effects. A trip sitter can help you with this.
Dextrose can help against circulatory problems.
Avoid roads and other "dangerous" places, your orientation may be disturbed.
Drink enough water during the trip.
Avoid mixed consumption at all costs, otherwise the effect can no longer be assessed.
Plan enough time for recovery after the trip (at least 1 day).
Mescaline trips should remain exceptional experiences.
In case of panic attacks or horror trips: stimulus shielding, keeping calm, "talk down/through".
People with mental problems or illnesses, people who need to take neuroleptics, and people, with heart problems should refrain from using mescaline.

Mixed use

Mixed use of this potent substance should be avoided at all costs, as the effect can then no longer be assessed.
Do not consume tramadol if you use psychedelic substances. Tramadol lowers the threshold for strokes, while psychedelic substances can trigger them in susceptible individuals.
Cannabis can have unexpected strong effects in combination with psychedelic substances, leading to anxiety, panic attacks and paranoia. Mixed use is discouraged or recommended, dosing cannabis lower than usual and taking long breaks in between.

Substances

3-CMC (Clophedrone)

3-MMC (3-methylmethcathinone)

4-FA

4-MMC (mephedrone)

6-APB

DOM - DOI - DOB

MDA - MDEA - MBDB

Methylone

Synthetic cannabinoids

Extender

No items found.

LSD analogues

LSD analogues are substances that are chemically very similar to LSD and can have comparable effects. Some of them have been known for a long time (e.g. ALD52, ETH-LAD, AL-LAD, PRO-LAD etc.) and have been studied pharmacologically as well as psychopharmacologically, at least in part. Others are newer "creations" (e.g. the derivatives 1P-LSD,1B-LSD, 1cP-LSD, 1V-LSDetc.), for which only few or no data are available. Certain LSD analogues can (still) be legally produced, traded and consumed in some countries, which is the main reason for their distribution.

Most LSD analogues are naturally different from LSD in their effect and/or potency (e.g. ETH-LAD, AL-LAD, LSZ etc.). In contrast, the so-called 1-acylated LSD compounds (e.g. 1P-LSD, 1V-LSD, 1B-LSD, ALD-52, etc.) are presumed, on the basis of pharmacological studies, to convert into LSD in the body (they function as so-called prodrugs) and thus have a comparable psychoactive effect to LSD.

In the case of prodrugs of LSD and LSD analogues, it has not been conclusively clarified whether, in addition to their psychoactive effect, they can produce other pharmacological effects. How potent these prodrugs are compared to the resulting substance (e.g., 1P-LSD to LSD), and to what extent a delay in onset of action occurs in each case, may be substance-dependent and cannot be generalized. Therefore, it is important to approach the dose/effect carefully to avoid overdoses.

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Mescaline

Effect

Duration

Dosage

Risks

Medicines

Emergency

Things to know

Current warnings

Advisory service

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Effect

Duration

Dosage

Risks

Effect

Dosage

Risks

Safer Use

Mixed use

Substances

Sex

Extender

LSD analogues

Medicines

Synthesis impurities

Emergency

Things to know

Current warnings

Advisory service

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