Quick info

NEP (N-ethylpentedrone) and NEH (N-ethylhexedrone) are new psychoactive substances and belong to the class of synthetic cathinones. They are effective even at low doses. The effects of both substances are described as energizing, focus-enhancing, and stimulating. Compared to well-known cathinones such as 3-MMC or 4-MMC (mephedrone), the high is often experienced as “cooler” and more functional.
The effects are described as highly stimulating, mood-enhancing, and boosting energy and concentration. Both substances ensure that the neurotransmitters dopamine and norepinephrine can remain active longer in the brain. This leads to the highly stimulating effect, which is often described as a mix between amphetamine and cocaine. They have only a weak effect on the neurotransmitter serotonin, which is why the “sense of connection” associated with MDMA is largely absent. According to user reports, the effects include increased talkativeness, greater self-confidence, and heightened sexual desire. A very strong urge to take another dose is typical of both substances, especially when snorted.
Onset of effects:
Snorted: after a few minutes
Swallowed: after 20–60 minutes
Duration of effect
Snorted: approx. 2–4 hours
Swallowed: approx. 4–6 hours
According to user reports, the energizing and stimulating effect lasts significantly longer—especially when another dose is taken—and often leads to difficulty falling asleep
The following information is based on user reports and has not been scientifically verified. Both substances are effective even in small amounts. There is a fine line between the desired effect and unpleasant side effects. Keep your dosage low and proceed with caution.
NEP (snorted)
Mild: 10–20 mg
Moderate: 20–40 mg
Strong: 40–60 mg
NEP (swallowed)
Mild: 10–25 mg
Moderate: 25–40 mg
Severe: 40–60 mg
NEH (snorted)
Mild: 15–30 mg
Medium: 30–40 mg
Strong: 40–50 mg
There is very little reliable information available on ingesting NEH. Proceed with extreme caution here. There is no evidence regarding rectal, smoked, or intravenous use of either substance. These methods of use should be avoided. If you do try them anyway, keep the dose as low as possible (about 50% of the amount you would snort)
Forms:
Crystalline, white to yellowish powder; less commonly available in capsule or tablet form.
Even at low doses, NEP and NEH can significantly increase the heart rate. Other side effects may include high blood pressure, cardiac arrhythmias, constricted blood vessels with cold hands and feet, dehydration, dry mouth, increased sweating, teeth grinding, loss of appetite, temporary erectile dysfunction, as well as restlessness, anxiety, and paranoia (ranging from severe distrust to fear of being persecuted). At high doses or with prolonged use, psychotic states (loss of touch with reality accompanied by delusions or hallucinations) are possible.
The urge to take another dose (“craving”) is particularly strong, especially when one has a cold. As a result, people often take another dose too quickly and in excessive amounts, which intensifies the side effects and increases the risk of addiction. The comedown can be accompanied by anxiety, low mood, irritability, headaches, and a lack of motivation. Many users report long-lasting difficulty falling asleep after use.
NEP and NEH are new psychoactive substances that have been little studied. Little is known about exactly how they affect the body or what long-term effects they may have. The current state of knowledge is based almost exclusively on reports from users.
NEP and NEH are currently often mistakenly sold as 3-MMC or 4-MMC. Anyone expecting 3-MMC or 4-MMC may therefore unknowingly consume one of these two stronger cathinones and inadvertently take too much. This situation stems from the volatile cathinone market since 2022, where inexpensive, poorly researched substances are constantly being sold under the names of better-known substances. The actual content can only be reliably determined through drug testing. Therefore, be sure to have your substances analyzed.
If you or someone else needs urgent help after taking drugs or alcohol, call an ambulance on 144. Tell the emergency responders everything you know.
It could save lives.