Quick info
Ketamine is a synthetic anesthetic and belongs to the dissociatives. The mode of action is strongly dependent on the amount consumed. Ketamine is used, usually in low doses, as a party drug, but in higher doses it can trigger strong extra-physical, psychedelic experiences ("K-Hole"). In addition, ketamine is used in psychiatry as a rapid-acting antidepressant for treatment-resistant depression.
The effect of ketamine as an intoxicant is strongly dependent on the dosage: in lower doses it has a disinhibiting and relaxing effect, similar to alcohol, while higher doses can induce trance-like states up to out-of-body or near-death experiences ("K-Hole"). There may be a fragmentary dissolution of the environment and bodily sensation, thoughts may break off, feelings of weightlessness or floating may emerge. Sensory perceptions and the space-time sensation change.
At very high dosages, detachment from one's own body and/or ego dissolution or fusion with the environment may occur. After the trip: drowsiness, memory of the experience is often only partially possible.
Onset of action:
Snorted: after 5 - 10 minutes
Swallowed: after 15 - 20 minutes
Injected intramuscularly: 2 - 5 minutes
Injected intravenously: within seconds
Duration of effect:
45 minutes - 2 hours depending on dose and form of consumption.
The dosage of ketamine is highly dependent on the desired effect. In party settings, usually only a few milligrams are snorted to achieve the desired effect. A higher dosage produces a more intense effect and is not recommended in party settings.
Snorted
Light: 10 - 30 mg
Medium: 30 - 75 mg
Strong: 75 - 150 mg
Swallowed
Light: 50 - 100 mg
Medium: 100 - 300 mg
Strong: 300 - 450 mg
Injected intramuscularly
70 - 150 mg
Injected intravenously
~ 50 mg
Appearances
white, crystalline powder or "sticks". More rarely liquid as a solution.
Movement and communication may be severely restricted. Partial or complete insensitivity to pain, coordination disorders, sensation of weakness, loss of appetite, nausea, vomiting, uncoordinated muscle movements, dizziness, slurred speech, increased pulse and blood pressure and cardiac arrhythmias. At high doses, muscle stiffness, paralysis and narcosis, at very high doses, epileptic seizures and coma.
Ketamine puts a strain on the cardiovascular system. A ketamine trip can be psychologically very stressful. Many ketamine users report near-death experiences, nightmare hallucinations, tunnel visions, blackouts and short periods of memory loss. After repeated use over a short period of time, the effect wears off considerably and tolerance builds up.
Long-term risks
Ketaminecan cause dependence with psychological symptoms. Chronic use damages the liver, bladder, and kidney and can lead to depressive moods and anxiety. It is thought that even in small doses, ketamine can cause dysfunction in areas of the brain responsible for memory, learning, and cognition. The more often it is consumed and the larger the individual doses, the more alarming these disturbances become.
Increased risk behavior due to the narcotic effect and loss of reality.
LSD analogues are substances that are chemically very similar to LSD and can have comparable effects. Some of them have been known for a long time (e.g. ALD52, ETH-LAD, AL-LAD, PRO-LAD etc.) and have been studied pharmacologically as well as psychopharmacologically, at least in part. Others are newer "creations" (e.g. the derivatives 1P-LSD,1B-LSD, 1cP-LSD, 1V-LSDetc.), for which only few or no data are available. Certain LSD analogues can (still) be legally produced, traded and consumed in some countries, which is the main reason for their distribution.
Most LSD analogues are naturally different from LSD in their effect and/or potency (e.g. ETH-LAD, AL-LAD, LSZ etc.). In contrast, the so-called 1-acylated LSD compounds (e.g. 1P-LSD, 1V-LSD, 1B-LSD, ALD-52, etc.) are presumed, on the basis of pharmacological studies, to convert into LSD in the body (they function as so-called prodrugs) and thus have a comparable psychoactive effect to LSD.
In the case of prodrugs of LSD and LSD analogues, it has not been conclusively clarified whether, in addition to their psychoactive effect, they can produce other pharmacological effects. How potent these prodrugs are compared to the resulting substance (e.g., 1P-LSD to LSD), and to what extent a delay in onset of action occurs in each case, may be substance-dependent and cannot be generalized. Therefore, it is important to approach the dose/effect carefully to avoid overdoses.
If you or someone else needs urgent help after taking drugs or alcohol, call an ambulance on 144. Tell the emergency responders everything you know.
It could save lives.