Substances / Psilocybin / Psilocin

Hallucinogenic mushrooms with the active ingredient psilocybin grow in the wild and were used by indigenous cultures as a medicinal and intoxicating agent. Best-known varieties: pointed cone bald(Psilocybe semilanceata), "Mexican"(Psilocybe cubensis) and "Hawaiian"(Panaeolus cyanescens or Copelandia cyanescens). When ingested, psilocybin is converted by the body into the breakdown product psilocin, which is responsible for the psychoactive effect of the mushrooms in the first place. Psilocin exerts its psychoactive effect primarily through the activation of certain serotonin receptors. Clinical research is currently investigating psilocybin as a possible treatment for various psychiatric disorders.

Effect

Deep doses: stimulating, slightly euphoric, laughing flash

Medium doses: mildly hallucinogenic and stimulates the imagination

High doses: strongly hallucinogenic, very psychedelic. Altered sense of space-time and ego - time expands, the environment is often perceived as dreamlike; visionary immersion in strange worlds, the sensation of deep insight into oneself and a feeling of strong connection with nature.

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Duration

Onset of effect

between 15-60 min.

Duration of action

3-7 hrs, depending on variety and preparation.

Aftereffects

6 hrs.

EFFECT (of pure psilocybin)

Onset of effect

After 20 - 40 min; peak: after 60 - 90min

Duration of action

120 - 210 min (2 - 3,5h)

Appearances

Fresh or dried mushrooms, "Magic Truffles" (Amsterdam); synthetic (pure) psilocybin as a white powder.

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Dosage

The active ingredient content is subject to strong fluctuations.

Average dosages of dried* mushrooms:

Pointed cone baldy light: 0.5-0.8 g, medium to heavy 0.8-max. 3 g

"Hawaiian": light 0.3-0.5 g, medium to strong 0.5-max. 2 g

"Mexican": light 0.5-1.5 g, medium to strong 1.5-max. 6 g

*for fresh mushrooms tenfold

Forms of consumption
eaten, drunk in tea, rarely smoked (reduced effect).

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Dosage of pure psilocybin:

µg/kg - effect

45µg/kg - mild to moderate effect

115µg/kg - medium effect

215µg/kg - medium to strong effect

315µg/kg - very strong effect (dosages above 25mg per total intake should be avoided).

Gender does not affect the dosage, but age does. The older one is, the less unwanted side effects and anxiety occur. This is probably due to the learned better handling of negative feelings as well as the reduction of serotonin receptors, to which psilocybin binds, with increasing age.

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For more information on dosage, see our Dosage Magic Mushrooms factsheet.

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Risks

Pupils dilate, pulse and blood pressure rise, increase in body temperature (sweating), breathing difficulties and palpitations may occur. Occasionally, nausea and circulatory collapse (especially in combination with alcohol) may occur. Also possible are balance disorders, confusion and anxiety in the context of so-called "bad trips"; panic attacks and later trauma sequelae may occur in the case of a "bad trip".

Long-term risks:

Psychoses can be triggered if there is a vulnerability to them. As a result of a bad trip, a trauma sequelae disorder can occur (post-traumatic stress disorder). Although rare, flashback phenomena can occur after psilocybin use, as with all psychedelics, which can be psychologically very stressful in the long term. Psilocybin dependence is not known.

Safer Use

When picking mushrooms in nature, there is a risk of confusion due to deadly doubles, so always keep a mushroom in case of poisoning!
Pay attention to the set: consume mushrooms only rested and in good mental and physical condition.
Pay attention to the setting: a protected setting is important; mushrooms are not party drugs. Do not use mushrooms alone, but with a companion you trust. Avoid streets and other "dangerous" places, your orientation can be disturbed.
Consume a light meal before the trip; eat very little 6 to 8 hours beforehand to avoid nausea and other unpleasant side effects.
Use dried mushrooms if possible; wash raw mushrooms well before eating. Chew well!
In delicate moments during the trip: let yourself go, do not try to fight the effect of the mushrooms.
Avoid mixed consumption, do not consume mushrooms together with alcohol under any circumstances!
In case of panic attacks or horror trips: see "In case of emergency".
After the trip, allow yourself plenty of rest and recovery, at least the day after, to be able to process the experience.
Individuals with high blood pressure, clotting disorders, or other cardiovascular conditions should refrain from consumption due to the potential for serious side effects (heart attack, stroke, embolism, death).
Mushrooms or pure psilocybin should not be taken concurrently (on the same day) with psychotropic drugs when taking psychotropic drugs or antimigraine drugs that also act on the serotonin system (antidepressants, opiate pain relievers, triptans), as life-threatening serotonin syndrome may result.
People who have first-degree relatives suffering from chronic psychosis should refrain from consumption, as they are at increased risk of triggering psychosis.

Mixed use

Avoid mixed consumption, never consume mushrooms together with alcohol or medication!

Refrain from mixed use with lithium. There is an increased risk of psychosis and stroke.

Do not consume tramadol if you use psychedelic substances. Tramadol lowers the threshold for strokes, while psychedelic substances can trigger them in susceptible individuals.

Cannabis can have unexpected strong effects in combination with psychedelic substances, leading to anxiety, panic attacks and paranoia. Mixed use is discouraged or recommended, dosing cannabis lower than usual and taking long breaks in between.

Substances

3-CMC (Clophedrone)

3-MMC (3-methylmethcathinone)

4-FA

4-MMC (mephedrone)

6-APB

DOM - DOI - DOB

MDA - MDEA - MBDB

Methylone

Synthetic cannabinoids

Extender

No items found.

LSD analogues

LSD analogues are substances that are chemically very similar to LSD and can have comparable effects. Some of them have been known for a long time (e.g. ALD52, ETH-LAD, AL-LAD, PRO-LAD etc.) and have been studied pharmacologically as well as psychopharmacologically, at least in part. Others are newer "creations" (e.g. the derivatives 1P-LSD,1B-LSD, 1cP-LSD, 1V-LSDetc.), for which only few or no data are available. Certain LSD analogues can (still) be legally produced, traded and consumed in some countries, which is the main reason for their distribution.

Most LSD analogues are naturally different from LSD in their effect and/or potency (e.g. ETH-LAD, AL-LAD, LSZ etc.). In contrast, the so-called 1-acylated LSD compounds (e.g. 1P-LSD, 1V-LSD, 1B-LSD, ALD-52, etc.) are presumed, on the basis of pharmacological studies, to convert into LSD in the body (they function as so-called prodrugs) and thus have a comparable psychoactive effect to LSD.

In the case of prodrugs of LSD and LSD analogues, it has not been conclusively clarified whether, in addition to their psychoactive effect, they can produce other pharmacological effects. How potent these prodrugs are compared to the resulting substance (e.g., 1P-LSD to LSD), and to what extent a delay in onset of action occurs in each case, may be substance-dependent and cannot be generalized. Therefore, it is important to approach the dose/effect carefully to avoid overdoses.

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Psilocybin / Psilocin

Effect

Duration

Dosage

Risks

Medicines

Emergency

Things to know

Current warnings

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Effect

Duration

Dosage

Risks

Effect

Dosage

Risks

Safer Use

Mixed use

Substances

Sex

Extender

LSD analogues

Medicines

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Emergency

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Current warnings

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