Sleep disturbances, irritability, aggressiveness, exaggerated egocentrism up to "megalomania", decrease in critical and judgemental ability, anxiety and delusions, depression, memory/concentration disorders, shortness of breath, hyperactivity, nervous twitching, muscle cramps and tremors, high stress on the cardiovascular system due to constriction of the blood vessels, increase in heart rate, increased blood pressure and hypertensive crises. In extreme cases, overdose can lead to a heart attack or stroke.
When the effect wears off: exhaustion, depressive moods, irritability, feelings of anxiety and a strong urge to take the drug again ("craving").
In case of chronic use: psychological dependence. "Craving" (irresistible and uncontrollable desire to consume) can be rapidly triggered by so-called trigger effects (situations, memories, people, and the like, which are associated with consumption). Other long-term risks are anxiety disorders, personality changes such as reduction of empathy, emotional coldness, exaggerated mistrust, depression, mental disorders with paranoid delusions and hallucinations, alteration of thought processes, permanent disturbances of short-term memory and intellectual abilities. Nerve damage, nervous twitching, seizures, alterations in movement patterns, damage to: Heart, liver, kidneys, lungs, skin, blood vessels and teeth. General weakening of the immune system, in extreme cases with necrosis (death of skin cells), liver damage due to the breakdown of toxins and the risk of kidney damage due to extender.
Chronic inflammation and damage to the nasal mucous membranes and nasal septum, which is difficult to heal. When smoking freebase and crack, damage to the lungs and respiratory tract is possible due to the deposition of combustion residues (ash residues). When injecting or smoking (freebase), the phenomenon of "dermatozoan madness" (the idea that there are worms or insects under the skin, perception of a tingling sensation under the skin) is known. Colloquially also called "cocaine worms/bugs"). This delusion leads to excessive scratching of the arms and/or legs, up to open injuries, which can lead to abscesses if hygiene is poor.