Sleep disorders, irritability, aggressiveness, anxiety and delusions, depression, memory/concentration disorders, hyperactivity; nervous twitching and stereotyped movements, muscle cramps and tremors, nerve damage, constriction of blood vessels, increase in heart rate, increased blood pressure. Hypertensive crises, in extreme cases cardiac arrhythmias, heart attack or stroke. Liver damage due to the breakdown of toxins. Some extenders are additionally harmful to health (see card "Sold as ..."). When smoking freebase and crack, damage to the oral cavity, lungs and respiratory tract is possible; when snorting, tissue destruction/destruction on the mucous membranes can occur. The simultaneous use of cocaine and alcohol increases the side effects and harmfulness; especially the heart is additionally stressed.
The lethal dose is about 1-1.2 g, although particularly sensitive individuals (cocaine idiosyncrasy) can die at doses as low as 30 mg.
In chronic use: Dependence with predominantly psychological symptoms, "craving" (uncontrollable desire to consume) - cocaine is one of the substances with the highest dependence potential and is more quickly addictive than most other substances - internal drive, anxiety disorders, personality changes, depressive states with suicidality, cocaine psychosis with paranoid delusions (persecutory experience) and hallucinations, alteration of thought processes, permanent disturbances of short-term memory; nervous twitching, seizures, persistent high blood pressure, alterations in movement patterns, chronic inflammation and damage to the nasal mucosa and nasal septum that is difficult to heal, damage to the heart, liver, kidneys, lungs, skin, blood vessels (e. g. e.g. inflammation of blood vessels up to occlusion with death of surrounding tissue, especially by levamisole) and teeth, blood count changes with consequent weakening of the immune system (by levamisole). With intravenous application abscesses, itching and tingling.With chronic consumption: psychological dependence. "Craving" (irresistible and uncontrollable desire to consume) can be rapidly triggered by so-called trigger effects (situations, memories, people, and the like, which are associated with consumption). Other long-term risks are anxiety disorders, personality changes such as reduction of empathy, emotional coldness, exaggerated mistrust, depression, mental disorders with paranoid delusions and hallucinations, alteration of thought processes, permanent disturbances of short-term memory and intellectual abilities. Nerve damage, nervous twitching, seizures, alterations in movement patterns, damage to: Heart, liver, kidneys, lungs, skin, blood vessels and teeth. General weakening of the immune system, in extreme cases with necrosis (death of skin cells), liver damage due to the breakdown of toxins and the risk of kidney damage due to extender.
Chronic inflammation and damage to the nasal mucous membranes and nasal septum, which is difficult to heal. When smoking freebase and crack, damage to the lungs and respiratory tract is possible due to the deposition of combustion residues (ash residues). When injecting or smoking (freebase), the phenomenon of "dermatozoan madness" (the idea that there are worms or insects under the skin, perception of a tingling sensation under the skin) is known. Colloquially also called "cocaine worms/bugs"). This delusion leads to excessive scratching of the arms and/or legs, up to open injuries, which can lead to abscesses if hygiene is poor.